Research & Development/Project

Development of Gene therapy & vision regeneration

 
Retinal Regenerative Gene Therapy

Recognises all spectrum from blue to red (in black-and-white images) and high resolution
Single injection therapy with minimal burden on the patients
No medical devices, e.g., artificial retinal chip
No cancerous risk of stem cell therapies


Patents and Publications

Patents

1.oF2009/8/10, PCT/JP2010/063786, 2009-185455, ̖́FPꂽe`lhvV
2. Date of Patent@Jun.17, 2014, Patent No:@US 8,754,048B2, Title: Light-receiving channel rhodopsin having improved expression efficiency.

Publications

1. Invest Ophthalmol Vis Sci. 2007 Aug;48(8):3821-6@gVisual responses in aged dystrophic RCS rats were restored by AAV-mediated channelopsin-2 gene transfer.h Tomita H, et al.,
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3. PLoS ONE, November 2009, Volume 4, Issue 11, gVisual Properties of Transgenic Rats Harboring the Channelrhodopsin-2 Gene Regulated by the Thy-1.2 Promoter.h Tomita H, et al.,, Wang H, Sugiyama Y, Hikima T, Sugano E, Tomita H, Takahashi T, Ishizuka T, Yawo H@
4. The Journal of Biological Chemistry, 2009 Feb 27;284(9):5685-96. Epub 2008 Dec 22. gMolecular determinants differentiating photocurrent properties of two channelrhodopsins from chlamydomonas.h
5. Experimental Eye Research, 2010 Mar;90(3):429-436. Epub 2009 Dec 27., gChannelrhodopsin-2 gene transduced into retinal ganglion cells restores functional vision in genetically blind rats.h Tomita H, et al.,
6. Journal of Genetics, 2009 Dec;88(4):409-15. gChannelrhodopsins provide a breakthrough insight into strategies for curing blindness.h Tomita H, et al.,
@ 7. PLoS One. @2009 Nov 5;4(11):e7679. gVisual properties of transgenic rats harboring the channelrhodopsin-2 gene regulated by the thy-1.2 promoter.h Tomita H, et al.,
@ 8. J Genet. 2009 Dec;88(4):409-15. Review. gChannelrhodopsins provide a breakthrough insight into strategies for curing blindness.h Tomita H, et al.,
@ 9. Exp Eye Res. 2010 Mar;90(3):429-36. Epub 2009 Dec 27. gChannelrhodopsin-2 gene transduced into retinal ganglion cells restores functional vision in genetically blind rats.h Tomita H, et al.,
10. PLoS One. 2010 Nov 29;5(11):e15009. gDissecting a role for melanopsin in behavioural light aversion reveals a response independent of conventional photoreceptionh Semo M, Gias C, Ahmado A, Sugano E, Allen AE, Lawrence JM, Tomita H, Coffey PJ, Vugler AA.
11. Gene Therapy 2011, 18(3) 266-74. gImmune responses to adeno-associated virus type 2 encoding channelrhodopsin-2 in a genetically blind rat model for gene therapy.h Sugano E, Isago H, Wang Z, Murayama N, Tamai M, Tomita H.
12. J Mol Neurosci. 2012 Feb;46(2):393-400. Epub 2011 Jul 27. gAge-Dependent Differences in Recovered Visual Responses in Royal College of Surgeons Rats Transduced with the Channelrhodopsin-2 Gene.h Isago H, Sugano E, Wang Z, Murayama N, Koyanagi E, Tamai M, Tomita H.
13. PLoS One. 2013 Apr 10;8(4):e60928. doi: 10.1371/journal.pone.0060928. Print 2013. gOptogenetically induced seizure and the longitudinal hippocampal network dynamics.h Osawa S, Iwasaki M, Hosaka R, Matsuzaka Y, Tomita H, Ishizuka T, Sugano E, Okumura E, Yawo H, Nakasato N, Tominaga T, Mushiake H.
14. BMC Ophthalmol. 2013 May 17;@13:19. @doi: 10.1186/1471-2415-13-19. gEstablishment of monocular-limited photoreceptor degeneration models in rabbits.h Isago H, Sugano E, Murayama N, Tamai M, Tomita H.
15. Mol Ther. 22(8):1434-40.2014. gRestoration of the majority of the visual spectrum by using modified Volvox channelrhodopsin-1.h Tomita H, et al.,